100% committed to ending dementia. For good.

All in to end Alzheimer disease.

CLEAR is the only Canadian foundation that directs 100% of funds raised to promising scientific research into the cause, prevention, and treatment of Alzheimer disease and other dementias.

Because it’s clear: the only path to a cure is more research.

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650K+

people living with dementia in Canada

Even more alarmingly, by 2031 this number is expected to exceed 1 million.

40

research projects funded by CLEAR

Each of these projects has contributed to our collective understanding of dementia.

8th

leading cause of death in Canada

Every year, over 6,000 Canadians die from the disease. That’s 16 loved ones lost each day.

$15M+

of funding provided to researchers

We will keep funding promising research until we have the cure the world has been waiting for.

Past & Present Research

Neurally-produced estradiol enhances the neuroprotective actions of insulin

Q: What did we learn? Dr. Mehran’s hypothesis was that estradiol produced by neurons enhances the production and action of insulin in the brain, and that this would have beneficial effects in a rat model of Alzheimer’s disease. However, even using some of the most sensitive assays, they failed to yield a difference. However, Dr.…

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Targeting Amyloid Propagation in Alzheimer Disease: Structures, Immunology and Extracellular Vesicle Topology

Q: What did we learn? We know that Abeta oligomers, a “seeding species” in Alzheimer’s disease, are predominantly spread in the brain via naked protein aggregates, and not through extracellular vesicles. Q: Why is this knowledge important? The development of oligomer-specific antibodies (Acumen, ProMIS Neurosciences) has enabled selective immunotherapies for Alzheimer’s disease that target the…

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Examining the effect of aerobic exercise on cognitive decline in older men and women, with mild cognitive impairment.

ABSTRACT Worldwide, one new case of dementia is detected every four seconds; there is currently no effective drug therapy. Given the greater prevalence of Alzheimer’s disease and its faster rate of progression from mild cognitive impairment to Alzheimer’s disease in women compared to men, it is essential to assess sex differences in studies relating to…

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Non-invasive imaging of Alzheimer Disease biomarkers in the brain and eye

ABSTRACT Age related neurodegenerative diseases such as Alzheimer’s Disease (AD) affect ~500,000 Canadians, and the economic burden of dementia was $15 billion in 2008. Early diagnosis and novel therapies are needed to improve the quality of life of affected individuals, and to reduce costs to the Canadian health care system. However, screening for irreversible hallmarks…

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Together, we can find a cure for Alzheimer disease.

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