100% committed to ending dementia. For good.

All in to end Alzheimer disease.

CLEAR is the only Canadian foundation that directs 100% of funds raised to promising scientific research into the cause, prevention, and treatment of Alzheimer disease and other dementias.

Because it’s clear: the only path to a cure is more research.

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650K+

people living with dementia in Canada

Even more alarmingly, by 2031 this number is expected to exceed 1 million.

40

research projects funded by CLEAR

Each of these projects has contributed to our collective understanding of dementia.

8th

leading cause of death in Canada

Every year, over 6,000 Canadians die from the disease. That’s 16 loved ones lost each day.

$15M+

of funding provided to researchers

We will keep funding promising research until we have the cure the world has been waiting for.

Past & Present Research

Examining the effect of aerobic exercise on cognitive decline in older men and women, with mild cognitive impairment.

ABSTRACT Worldwide, one new case of dementia is detected every four seconds; there is currently no effective drug therapy. Given the greater prevalence of Alzheimer’s disease and its faster rate of progression from mild cognitive impairment to Alzheimer’s disease in women compared to men, it is essential to assess sex differences in studies relating to…

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Can the loss of brain-derived insulin cause Alzheimer’s disease

ABSTRACT There are some fundamental questions related to Alzheimer’s disease that have not yet been answered satisfactorily. In some cases, the tools were not previously available to answer these questions. This project will investigate the role of brain insulin in Alzheimer’s disease using new state-of-the-art genetically engineered models because it has the potential to change…

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The role of smooth muscle cell metabolism of amyloid beta in cerebral amyloid angiopathy

Q: What did we learn? Leakage of blood vessels in the brain due to build up the protein amyloid beta is thought to be a significant cause of dementia in both Alzheimer’s disease and vascular dementia. In the blood vessels there is loss of smooth muscle cells (SMCs), the main cell type in arteries, and…

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Contribution of microglia activation and neuronal oxidative stress to Alzheimer’s disease

ABSTRACT Recent studies have indicated that microglia, our protective immune cell in the brain, might be important in causing the loss of nerve cells in Alzheimer disease. To further understand these processes, we will study how microglia cause oxidative stress, a phenomenon that causes an over production of reactive oxygen radicals. We recently found that…

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Together, we can find a cure for Alzheimer disease.

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