Project Title: Alzheimer brain through 3D bioprinting patient-derived stem cells

Grant Name: 2025 Trainee Award, jointly funded by Health Research BC 

Grant Duration: 2025-2027 (two years)

Research Lay Summary:

Alzheimer’s disease (AD) is the leading cause of dementia, affecting over 55 million people worldwide. With no cure or prevention, AD remains a high priority challenge for the Canadian healthcare system. Researchers also struggle to develop effective treatments due to poor lab models that do not fully mimic the human brain.

Dr. Sorrentino's research will aim to create an advanced 3D brain model using patient-derived stem cells to better study early AD stages, focusing on the role of the Amyloid beta protein. By creating a more accurate brain model, his work will help us understand AD more clearly and find new treatment options without the need for animal testing. Findings will be shared widely with stakeholders and patients’ organizations. In addition, a group of people with dementia and their caregivers will share their experiences to help guide this research, ensuring the project is patient-focused and promotes mutual learning.